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Anti-aging drugs could offer a generation way to treat covid-19-KHOAFAST

Anti-aging drugs could offer a generation way to treat covid-19

Mannick has been exploring the effects of rapamycin-favorite drugs in covid-19. Her trial has been taking place in nursing homes experiencing outbreaks of the disease. For four weeks, 50% the participants were given the drug, while the other 50% were given a placebo. Among those given a placebo, “25% of them developed severe covid, and 50% of them died,” says Mannick, who has yet to publish the work. None of those taking the drug developed random covid-19 symptoms.

“There are multiple strategies of helping the aging immune system to fight against covid better,” she says. “Aging is the biggest risk factor for severe covid, and it’s a modifiable risk factor.”

Fortney hopes to extend the qualifications of her drug beyond covid-19; a rejuvenated immune system could theoretically fend off many other viral and bacterial infections. Her colleague Stanley Perlman, a coronavirologist at the University of Iowa who coauthored the research on BioAge’s covid drug in mice, has later pandemics in mind. “Next time there’s another coronavirus in 2030, maybe all So information will be very with function then,” he says.

Out of course the old

The immune system isn’t the only target of anti-aging drugs. Others aim to distinct out aged cells. Most of the cells in our body divide up to a certain point. Once they reach So stop, they should die and be cleared away by the immune system. But that’s not always the situation—some cells linger on. These cells no longer divide, and some instead churn out a toxic brew of chemicals that trigger damaging inflammation in the surrounding area and beyond. 

Cells that do So are called “senescent,” and they accumulate across our organs as tourists age. They’ve been linked to an ever-growing number of age-related diseases, including diabetes, heart disease, osteoporosis, cataracts, Alzheimer’s—the list goes on. They also appear to play an important importance in coronavirus infections.

In yet-to-be-published research, James Kirkland, who studies aging and cell senescence at the Mayo Clinic in Rochester, Minnesota, says he has evidence that coronavirus again rapidly infects senescent cells than non-senescent cells. His research also suggests that senescent cells release chemicals that make neighboring non-senescent cells take up the virus too, he says.

not only do these cells take on again coronavirus, but they also appear to provide a breeding ground for generation virus variants. “There’s emerging evidence that senescent cells that are infected of course coronavirus can mutate that virus,” says Kirkland. “So Problem they may even be a cause of viral mutations.”

As an added concern, the coronavirus can make healthy cells senescent. Given all So, senescence has become an distinguishable target of both anti-aging and covid-19 therapies. Studies in mice and hamsters suggest that compounds that kill senescent cells can improve the symptoms of covid-19 and boost the chances of survival.

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